GPR88 HEK293
| I. Background | |
GPR88 是 A 類視紫紅質(zhì)家族的孤兒 G 蛋白偶聯(lián)受體（GPCR）。GPR88 最初被確定為人類和嚙齒動物中的紋狀體特異性受體（指定為 Strg/GPR88），但它也在大腦皮層、中央延伸杏仁核、外側(cè)、皮質(zhì)、下丘腦和其他大腦區(qū)域中以低水平表達(dá)。 | |
| II. Description | |
GPR88 HEK293 藥靶模型很好的模擬了體內(nèi) GPR88 的信號轉(zhuǎn)導(dǎo)過程，原理見下圖所示。
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| III. Introduction | |
| Expressed gene: | GPR88 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional assay for GPR88 |
| Transducer: | Gi |
IV. Representative Data
Figure 2. HTRF cAMP Assay with GPR88 HEK293(C16). | |
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